PHARMACOLOGY OF PHLEBOLOGY Phillip Artemi MECHANISM OF ACTION OF SCLEROTHERAPY GENERAL MECHANISM FOR PRODUCING ENDOTHELIAL DAMAGE
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چکیده
Total endothelial destruction results in the exposure of sub-endothelial collagen fibers causing platelet aggregation, adherence, and release of platelet-related factors. This series of events initiates the intrinsic pathway of blood coagulation by activating factor XII. Ideally, sclerosing solutions otherwise should not cause activation or release of thromboplastic activity because this would initiate the extrinsic pathway of blood coagulation.
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